Elucidating the genetic code blind dating2016 review


08-Jun-2017 14:08

However, all of the above methods, though they were able to prioritize disease- and phenotypic-related genes, did not provide a coherent connected module in the PPI; thus, their ability to describe disease underlying mechanisms is limited.

Computational methods for associating genes with diseases often employ integrative approaches, exploiting different data sources such as Gene Ontology (GO) annotations [] created a statistical framework for constructing a sample-specific network describing an individual’s disease state.In particular, protein-protein interaction networks were successfully used to illuminate disease modules, i.e., interacting proteins working in concert to drive a disease.



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