Elucidating the genetic code blind dating2016 review
However, all of the above methods, though they were able to prioritize disease- and phenotypic-related genes, did not provide a coherent connected module in the PPI; thus, their ability to describe disease underlying mechanisms is limited.
Computational methods for associating genes with diseases often employ integrative approaches, exploiting different data sources such as Gene Ontology (GO) annotations  created a statistical framework for constructing a sample-specific network describing an individual’s disease state.In particular, protein-protein interaction networks were successfully used to illuminate disease modules, i.e., interacting proteins working in concert to drive a disease.
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